No accounting for taste? Giant sloths, ancient pumpkins, and evolutionary genetics in bitter taste receptors.

No accounting for taste? Giant sloths, ancient pumpkins, and evolutionary genetics in bitter taste receptors.

Though domesticated pumpkins and other gourds (think zucchinis, acorn squashes, butternut squashes), are edible (and tasty!), their wild cousins produce a toxic bitter compound, rendering them poisonous to humans, even in small amounts. Anyone who has ever picked a pumpkin and hauled it home might be wondering…why on earth would a plant produce fruit weighing more-than-some-dogs that no one can eat?

Well, its turns out there's an answer. And it involves some Jurassic Park level science (but better, because it's real). Read on, fellow nerds…

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Neurotalk S5E6: Tianyi Mao

Today, our guest is Dr. Tianyi Mao, Assistant Scientist and Principal Investigator at the Vollum Institute. We’ll talk about dissecting thalamo-cortical circuits in a systematic way; using sCRACM to understand how circuits are wired; how this approach and these maps could help us understand cortico-striatal-thalamic loops; and, how Dr. Mao’s got to where she is today.

Neurotalk S3E10: Takaki Komiyama

Our guest is in this episode is Takaki Komiyama, a professor at the University of California, San Diego in the Department of Neurosciences and in the Neurobiology Section of the Center for Neural Circuits and Behavior.

Small blast from the past: this episode was recorded in October, 2014, but never broadcast; we wanted to bring this back from our archives and present it to you now, because it’s a great interview!

In this interview, we talk about the anatomy of the sense of smell, baseball (Royals fans, sorry this was 2014...but we're in 2015 now), and neural ensembles in motor cortex during learning. Please enjoy!

How the immune system helps build your brain

How the immune system helps build your brain

Pregnant women who are hospitalized for infections, including the flu, have a slightly higher risk for giving birth to a child with a neurodevelopmental disorder like autism. What's going on? Is the immune system influencing the developing brain? 

Spoilers: yes. And it all starts when immune cells (microglia) are lured into the brain by the siren call of neural progenitor cells. 

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RNA Circles In Your Brain: Noise or a New Class of Genetic Regulators?

RNA Circles In Your Brain: Noise or a New Class of Genetic Regulators?

Molecular biology is still defined by its "central dogma," but we often don’t use the word dogma in science unless we are about to contradict it. Here, Nick Kramer tells us about how circular RNAs, a newly discovered, highly conserved class of RNA molecules, are abundant in the brain and may contribute to its development.

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Neurotalk S5E7: Marc Tessier-Lavigne

Today we'll be speaking with Marc Tessier-Lavigne, Carson Family Professor and at Rockefeller University. We'll be speaking with him about fundamental discoveries of new axon guidance molecules; his career path including many roles in both basic and translational science; and exciting unsolved mysteries in the field of axon guidance.

[Note: Our S5E6 interview with last week's speaker, Tianyi Mao, upcoming!]